Reaction: acetoacetyl-CoA + CoA <=> 2 acetyl-CoA
- in pathway: Utilization of Ketone Bodies
Acetyl-CoA acetyltransferase tetramer (ACAT1) in the mitochondrial matrix catalyzes the reversible reaction of acetoacetyl-CoA and CoA to form two molecules of acetyl-CoA (Middleton et al. 1986).
Reaction - small molecule participants:
Ac-CoA [mitochondrial matrix]
CoA-SH [mitochondrial matrix]
ACA-CoA [mitochondrial matrix]
Reactome.org reaction link: R-HSA-74181
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Reaction input - small molecules:
coenzyme A(4-)
acetoacetyl-CoA(4-)
Reaction output - small molecules:
acetyl-CoA(4-)
Reactome.org link: R-HSA-74181