Reaction: HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP
- in pathway: Purine salvage
Cytosolic hypoxanthine-guanine phosphoribosyltransferase (HPRT1) tetramer catalyzes the reactions of guanine or hypoxanthine with PRPP to form GMP ir IMP and pyrophosphate (Holden and Kelley 1978; Jolly et al. 1983).
Reaction - small molecule participants:
PPi [cytosol]
PRPP [cytosol]
Reactome.org reaction link: R-HSA-74215
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Reaction input - small molecules:
5-O-phosphonato-alpha-D-ribofuranosyl diphosphate(5-)
Reaction output - small molecules:
diphosphate(3-)
Reactome.org link: R-HSA-74215