Reaction: SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen
- in pathway: GDP-fucose biosynthesis
The human gene SLC35C1 encodes a GDP-fucose transporter that resides on the Golgi membrane and mediates the transport of GDP-fucose (GDP-Fuc) formed from a de novo pathway and/or a salvage pathway into the Golgi lumen. Defects in SLC35C1 cause the congenital disorder of glycosylation type 2C, also known as leukocyte adhesion deficiency type II (LAD2) (Lubke et al. 2001).
Reaction - small molecule participants:
GDP-Fuc [Golgi lumen]
GDP-Fuc [cytosol]
GDP-Fuc [Golgi lumen]
GDP-Fuc [cytosol]
Reactome.org reaction link: R-HSA-742345
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Reaction input - small molecules:
GDP-L-fucose
GDP-L-fucose
Reaction output - small molecules:
GDP-L-fucose
GDP-L-fucose
Reactome.org link: R-HSA-742345