Reaction: ADA catalyzes the deamination of (deoxy)adenosine
- in pathway: Purine salvage
Cytosolic adenosine deaminase (ADA) catalyzes the hydrolysis of 2'deoxyadenosine and adenosine to yield deoxyinosine and inosine, respectively, plus ammonia (Akeson et al. 1988). Unpublished crystallographic data (PDB 3IAR) indicate that the human enzyme is a monomer.
Reaction - small molecule participants:
NH4+ [cytosol]
H2O [cytosol]
Reactome.org reaction link: R-HSA-74241
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Reaction input - small molecules:
water
Reaction output - small molecules:
ammonium
Reactome.org link: R-HSA-74241