Reaction: PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose
- in pathway: Purine catabolism
Cytosolic purine nucleoside phosphorylase (PNP) trimer catalyzes the reversible reaction of guanosine or deoxyguanosine with orthophosphate to form guanine and ribose 1-phosphate or deoxyribose 1-phosphate (Ealick et al. 1990; Wiginton et al. 1980). PNP deficiency in vivo is associated with accumulation of guanosine and deoxyguanosine and leads to immunodeficiency (Williams et al. 1987).
Reaction - small molecule participants:
Gua [cytosol]
Pi [cytosol]
Reactome.org reaction link: R-HSA-74249
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Reaction input - small molecules:
hydrogenphosphate
Reaction output - small molecules:
guanine
Reactome.org link: R-HSA-74249