Reaction: Guanine + H2O => Xanthine + NH4+
- in pathway: Purine catabolism
Cytosolic guanine deaminase (GDA) catalyzes the reaction of guanine and water to form xanthine and ammonia (Yuan et al. 1999). The active enzyme is a homodimer (Murphy et al. 2009).
Reaction - small molecule participants:
NH4+ [cytosol]
XAN [cytosol]
H2O [cytosol]
H+ [cytosol]
Gua [cytosol]
Reactome.org reaction link: R-HSA-74255
======
Reaction input - small molecules:
water
hydron
guanine
Reaction output - small molecules:
ammonium
9H-xanthine
Reactome.org link: R-HSA-74255