Reaction: SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP
- in pathway: Transport of nucleotide sugars
The human gene SLC35D2 encodes the UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter (UGTREL8; homolog of Fringe connection protein 1, HFRC1). It resides on the Golgi membrane where it mediates the antiport of GDP-mannose into the Golgi lumen in exchange for GMP (Suda T et al, 2004; Ishida N et al, 2005).
Reaction - small molecule participants:
GMP [cytosol]
GDP-Man [Golgi lumen]
GDP-Man [cytosol]
GMP [Golgi lumen]
Reactome.org reaction link: R-HSA-744230
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Reaction input - small molecules:
GDP-alpha-D-mannose(2-)
guanosine 5'-monophosphate(2-)
Reaction output - small molecules:
guanosine 5'-monophosphate(2-)
GDP-alpha-D-mannose(2-)
Reactome.org link: R-HSA-744230