Reaction: SLC35D2 exchanges UDP-GlcNAc for UMP
- in pathway: Keratan sulfate biosynthesis
The human gene SLC35D2 encodes the UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter (UGTREL8; homolog of Fringe connection protein 1, HFRC1). It resides on the Golgi membrane where it mediates the transport of nucleotide sugars including UDP-GlcNAc into the Golgi lumen in exchange for UMP (Suda et al. 2004, Ishida et al. 2005).
Reaction - small molecule participants:
UDP-GlcNAc [Golgi lumen]
UMP [cytosol]
UMP [Golgi lumen]
UDP-GlcNAc [cytosol]
UDP-GlcNAc [Golgi lumen]
UMP [cytosol]
UMP [Golgi lumen]
UDP-GlcNAc [cytosol]
UDP-GlcNAc [Golgi lumen]
UMP [cytosol]
UMP [Golgi lumen]
UDP-GlcNAc [cytosol]
Reactome.org reaction link: R-HSA-744231
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Reaction input - small molecules:
uridine 5'-monophosphate(2-)
UDP-N-acetyl-alpha-D-glucosamine(2-)
uridine 5'-monophosphate(2-)
UDP-N-acetyl-alpha-D-glucosamine(2-)
uridine 5'-monophosphate(2-)
UDP-N-acetyl-alpha-D-glucosamine(2-)
Reaction output - small molecules:
UDP-N-acetyl-alpha-D-glucosamine(2-)
uridine 5'-monophosphate(2-)
UDP-N-acetyl-alpha-D-glucosamine(2-)
uridine 5'-monophosphate(2-)
UDP-N-acetyl-alpha-D-glucosamine(2-)
uridine 5'-monophosphate(2-)
Reactome.org link: R-HSA-744231