Reaction: Endosome acidification
- in pathway: Insulin receptor recycling
The effect of the proton pump is to allow entry of [H+] ions into the lumen of the endosome. The net effect of this is to lower the pH of the lumen from pH 7.4 (the pH at the plasma membrane) to pH 6.0 (documented with studies using FITC-labeled insulin - a pH dependent fluorescence marker).
Reaction - small molecule participants:
H+ [endosome lumen]
H+ [cytosol]
Reactome.org reaction link: R-HSA-74723
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Reaction input - small molecules:
hydron
Reaction output - small molecules:
hydron
Reactome.org link: R-HSA-74723