Reaction: atROL binds RBP1 to form RBP1:atROL
- in pathway: The canonical retinoid cycle in rods (twilight vision)
Once all-trans-retinol (atROL) enters the retinal pigment epithelium (RPE) and before esterification takes place, atROL binds to cellular retinol-binding protein 1 (RBP1) (Folli et al. 2001). The resultant complex (RBP1:atROL) serves as a substrate for lecithin retinol acyltransferase (LRAT), the main enzyme responsible for the esterification of atROL.
Reaction - small molecule participants:
atROL [cytosol]
Reactome.org reaction link: R-HSA-74843
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Reaction input - small molecules:
all-trans-retinol
Reaction output - small molecules:
Reactome.org link: R-HSA-74843