Reaction: palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH
- in pathway: Plasmalogen biosynthesis
Peroxisomal glyceronephosphate O-acyltransferase (GNPAT) catalyzes the reaction of palmitoyl-CoA and DHAP to form 1-palmitoyl glycerone phosphate (1-palmitoyl dihydroxyacetone phosphate) and CoASH. The active form of the enzyme is one subunit of a heterotrimer with two molecules of the alkylglycerone phosphate synthase (AGPS) enzyme (Biermann et al. 1999). It was first purified and characterized biochemically by Ofman and Wanders (1994). Mutations in the GNPAT gene are associated with rhizomelic chondrodysplasia type 2 (Ofman et al. 1998, 2001).
Reaction - small molecule participants:
CoA-SH [peroxisomal matrix]
1-Palmitoyl dihydroxyacetone phosphate [peroxisomal matrix]
PalmCoA [peroxisomal matrix]
DHAP [peroxisomal matrix]
Reactome.org reaction link: R-HSA-75879
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Reaction input - small molecules:
palmitoyl-CoA(4-)
glycerone phosphate(2-)
Reaction output - small molecules:
coenzyme A(4-)
1-palmitoylglycerone 3-phosphate(2-)
Reactome.org link: R-HSA-75879