Reaction: glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated]
- in pathway: Triglyceride biosynthesis
Either of GPAM or GPAT2 (glycerol-3-phosphate acyltransferase, mitochondrial; glycerol-3-phosphate acyltransferase 2, mitochondrial) associated with the outer mitochondrial membrane catalyzes the reaction of cytosolic glycerol 3-phosphate and acyl-CoA to form 1-acylglycerol 3-phosphate and CoASH. The biochemical properties and location of human GPAM have been established through studies of the recombinant protein (Chen et al. 2008); those features of GPAT2 have been inferred from the properties of its rat homologue and those of GPAM. GPAM and GPAT2 differ in their their preferences for acyl-CoA substrates (Shindou & Shimizu 2009) and in their expression patterns in the body (Takeuchi & Reue 2009).
Reaction - small molecule participants:
CoA-SH [cytosol]
1-acyl LPA [cytosol]
FACoA [cytosol]
G3P [cytosol]
Reactome.org reaction link: R-HSA-75886
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Reaction input - small molecules:
fatty acyl-CoA(4-)
sn-glycerol 3-phosphate(2-)
Reaction output - small molecules:
coenzyme A(4-)
1-acyl-sn-glycerol 3-phosphate
Reactome.org link: R-HSA-75886