Reaction: DHAP is converted to G3P by GPD1/GPD1L
- in pathway: Synthesis of PA
Dihydroxyacetone phosphate (DHAP) is converted to glycerol-3-phosphate (G3P) by glycerol-3-phosphate dehydrogenase (GPD1) or by glycerol-3-phosphate dehydrogenase-like (GPD1L) enzymes (Ou et al. 2006, Valdivia et al. 2009). The active forms of both enzymes are homodimers. This reaction may be found in white adipose tissues where glycerol-3-kinase activity is not observed in sufficient levels. GPD1/GPD1L reduces dihydroxyacetone phosphate with NADH donating electrons to this reduction.
Reaction - small molecule participants:
G3P [cytosol]
NAD+ [cytosol]
H+ [cytosol]
DHAP [cytosol]
NADH [cytosol]
Reactome.org reaction link: R-HSA-75889
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Reaction input - small molecules:
hydron
glycerone phosphate(2-)
NADH(2-)
Reaction output - small molecules:
sn-glycerol 3-phosphate(2-)
NAD(1-)
Reactome.org link: R-HSA-75889