Reaction: Vinyl chloride is oxidized to 2-Chloroethylene oxide
- in pathway: CYP2E1 reactions
CYP2E1 can catalyze the oxidation of the vinyl halide vinyl chloride to the epoxide 2-chloroethylene oxide. The epoxide is very unstable and rearranges quickly to 2-chloroacetaldehyde. Both these products can interact with DNA and proteins.
Reaction - small molecule participants:
2CEO [endoplasmic reticulum lumen]
H2O [endoplasmic reticulum lumen]
NADP+ [endoplasmic reticulum lumen]
O2 [endoplasmic reticulum lumen]
H+ [endoplasmic reticulum lumen]
VC [endoplasmic reticulum lumen]
NADPH [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-76354
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Reaction input - small molecules:
dioxygen
hydron
chloroethene
NADPH
Reaction output - small molecules:
2-chlorooxirane
water
NADP(+)
Reactome.org link: R-HSA-76354