Reaction: N-hydroxylation of 4-aminobiphenyl
Heterocyclic and aromatic amines require metabolic activation to convert them to genotoxic metabolites.The initial step is N-hydroxylation and cytochrome P450 1A2 can carry out the catalysis.
Reaction - small molecule participants:
H2O [endoplasmic reticulum lumen]
NADP+ [endoplasmic reticulum lumen]
NHABP [endoplasmic reticulum lumen]
O2 [endoplasmic reticulum lumen]
H+ [endoplasmic reticulum lumen]
ABPH [endoplasmic reticulum lumen]
NADPH [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-76373
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Reaction input - small molecules:
dioxygen
hydron
biphenyl-4-amine
NADPH
Reaction output - small molecules:
water
NADP(+)
N-hydroxy-4-aminobiphenyl
Reactome.org link: R-HSA-76373