Reaction: CYP1A2 S-demethylates 6MMP
- in pathway: Methylation
At the beginning of this reaction, 1 molecule of 'H+', 1 molecule of '6-Methylmercaptopurine', 1 molecule of 'Oxygen', and 1 molecule of 'NADPH' are present. At the end of this reaction, 1 molecule of 'NADP+', 1 molecule of '6-Mercaptopurine', 1 molecule of 'Formaldehyde', and 1 molecule of 'H2O' are present.
This reaction takes place in the 'smooth endoplasmic reticulum' and is mediated by the 'oxygen binding activity' of 'Cytochrome P450 1A2 '.
This reaction takes place in the 'smooth endoplasmic reticulum' and is mediated by the 'oxygen binding activity' of 'Cytochrome P450 1A2 '.
Reaction - small molecule participants:
CH2O [endoplasmic reticulum lumen]
H2O [endoplasmic reticulum lumen]
NADP+ [endoplasmic reticulum lumen]
6MP [endoplasmic reticulum lumen]
O2 [endoplasmic reticulum lumen]
H+ [endoplasmic reticulum lumen]
6MMP [endoplasmic reticulum lumen]
NADPH [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-76386
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Reaction input - small molecules:
dioxygen
hydron
6-methylthiopurine
NADPH
Reaction output - small molecules:
formaldehyde
water
NADP(+)
purine-6-thiol
Reactome.org link: R-HSA-76386