Reaction: Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)
- in pathway: CYP2E1 reactions
N-acetyl-p-benzoquinone imine (NAPQI) is the reactive intermediate of the analgesic and antipyretic, acetaminophen (INN, paracetamol). At usual doses, NAPQI is quickly detoxified by conjugation but in overdose situations, NAPQI is extremely toxic to liver tissue.
Reaction - small molecule participants:
H2O [endoplasmic reticulum lumen]
NABQI [endoplasmic reticulum lumen]
NADPH [endoplasmic reticulum lumen]
O2 [endoplasmic reticulum lumen]
NADP+ [endoplasmic reticulum lumen]
Acetaminophen (TN TYLENOL) [endoplasmic reticulum lumen]
H2 [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-76397
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Reaction input - small molecules:
dioxygen
NADP(+)
paracetamol
dihydrogen
Reaction output - small molecules:
water
N-acetyl-1,4-benzoquinone imine
NADPH
Reactome.org link: R-HSA-76397