Reaction: Benzene is hydroxylated to phenol
- in pathway: CYP2E1 reactions
Benzene is an occupational and environmental toxicant and is implicated in myelogenous leukemia. For toxicity to occur, benzene is oxidised to phenol and subsequently to catechol and hydroquinone. CYP2E1 is the enzyme responsible for oxidation of benzene to phenol.
Reaction - small molecule participants:
H2O [endoplasmic reticulum lumen]
PhOH [endoplasmic reticulum lumen]
NADP+ [endoplasmic reticulum lumen]
O2 [endoplasmic reticulum lumen]
C6H6 [endoplasmic reticulum lumen]
H+ [endoplasmic reticulum lumen]
NADPH [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-76416
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Reaction input - small molecules:
dioxygen
benzene
hydron
NADPH
Reaction output - small molecules:
water
phenol
NADP(+)
Reactome.org link: R-HSA-76416