Reaction: Dehalogenation of carbon tetrachloride to form a free radical
- in pathway: CYP2E1 reactions
Carbon tetrachloride (CCl4) has been widely used as a dry-cleaning agent, in fire extinguishers and in the manufacture of other halogenated hydrocarbons. At toxic doses, CCl4 exposure can damage the liver and kidneys. This toxicity results from CYP2E1-dependant reduction of CCl4 to the reactive trichloromethyl radical (CCl3.).
Reaction - small molecule participants:
Cl- [endoplasmic reticulum lumen]
CCl4 [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-76434
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Reaction input - small molecules:
tetrachloromethane
Reaction output - small molecules:
chloride
Reactome.org link: R-HSA-76434