Reaction: Coumarin is 7-hydroxylated by CYP2A6
- in pathway: Xenobiotics
The 7-hydroxylation of coumarin is used as an assay of P450 activity in animal and human liver microsomes. CYP2A6 is the major coumarin 7-hydroxylase in human liver.
Reaction - small molecule participants:
H2O [endoplasmic reticulum lumen]
NADP+ [endoplasmic reticulum lumen]
HCOU [endoplasmic reticulum lumen]
O2 [endoplasmic reticulum lumen]
H+ [endoplasmic reticulum lumen]
COUM [endoplasmic reticulum lumen]
NADPH [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-76453
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Reaction input - small molecules:
dioxygen
hydron
coumarin
NADPH
Reaction output - small molecules:
water
NADP(+)
umbelliferone
Reactome.org link: R-HSA-76453