Reaction: O-atom dealkylation of dextromethorphan
- in pathway: Xenobiotics
At the beginning of this reaction, 1 molecule of 'H+', 1 molecule of 'Dextromethorphan', 1 molecule of 'Oxygen', and 1 molecule of 'NADPH' are present. At the end of this reaction, 1 molecule of 'NADP+', 1 molecule of 'Dextrorphan', 1 molecule of 'Formaldehyde', and 1 molecule of 'H2O' are present.
This reaction takes place in the 'smooth endoplasmic reticulum' and is mediated by the 'oxygen binding activity' of 'Cytochrome P450 2D6 '.
This reaction takes place in the 'smooth endoplasmic reticulum' and is mediated by the 'oxygen binding activity' of 'Cytochrome P450 2D6 '.
Reaction - small molecule participants:
CH2O [endoplasmic reticulum lumen]
H2O [endoplasmic reticulum lumen]
NADP+ [endoplasmic reticulum lumen]
O2 [endoplasmic reticulum lumen]
H+ [endoplasmic reticulum lumen]
NADPH [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-76456
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Reaction input - small molecules:
dioxygen
hydron
NADPH
Reaction output - small molecules:
formaldehyde
water
NADP(+)
Reactome.org link: R-HSA-76456