Reaction: CYP4A11 12-hydroxylates DDCX
- in pathway: Fatty acids
Dodecanoic acid (DDCX aka lauric acid) is a medium-chain fatty acid which serves as a model substrate for studying the CYP4A gene subfamily of cytochrome P450s. CYP4A11 and CYP2E1 are the principal isozymes involved in omega-hydroxylation and omega-1 hydroxylation respectively of DDCX.
Reaction - small molecule participants:
H2O [endoplasmic reticulum lumen]
NADP+ [endoplasmic reticulum lumen]
12OH-DDCX [endoplasmic reticulum lumen]
O2 [endoplasmic reticulum lumen]
H+ [endoplasmic reticulum lumen]
DDCX [endoplasmic reticulum lumen]
NADPH [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-76466
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Reaction input - small molecules:
dioxygen
hydron
dodecanoic acid
NADPH
Reaction output - small molecules:
water
NADP(+)
12-hydroxylauric acid
Reactome.org link: R-HSA-76466