Reaction: Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide
- in pathway: CYP2E1 reactions
The volatile anesthetic halothane can undergo CYP2E1-catalyzed oxidation to form a reactive intermediate which can acetylate liver proteins. These proteins can then stimulate an immune reaction that mediates severe hepatic necrosis ("halothane hepatitis").
Reaction - small molecule participants:
H2O [endoplasmic reticulum lumen]
NADP+ [endoplasmic reticulum lumen]
HBr [endoplasmic reticulum lumen]
TFAC [endoplasmic reticulum lumen]
O2 [endoplasmic reticulum lumen]
H+ [endoplasmic reticulum lumen]
HALO [endoplasmic reticulum lumen]
NADPH [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-76475
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Reaction input - small molecules:
dioxygen
hydron
halothane
NADPH
Reaction output - small molecules:
water
NADP(+)
hydrogen bromide
trifluoroacetyl chloride
Reactome.org link: R-HSA-76475