Reaction: TBXAS1 isomerises PGH2 to TXA2
- in pathway: Eicosanoids
Thromboxane synthase (TBXAS1) aka CYP5A1 mediates the isomerisation of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2) (Miyata et al. 2001, Chevalier et al. 2001). This reaction is not coupled with any P450 reductase proteins nor consumes NADPH.
Reaction - small molecule participants:
TXA2 [endoplasmic reticulum lumen]
PGH2 [endoplasmic reticulum lumen]
TXA2 [endoplasmic reticulum lumen]
PGH2 [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-76500
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Reaction input - small molecules:
prostaglandin H2
prostaglandin H2
Reaction output - small molecules:
thromboxane A2
thromboxane A2
Reactome.org link: R-HSA-76500