Reaction: NLRP1 senses MDP
- in pathway: The NLRP1 inflammasome
In vitro studies using purified NLRP1 and caspase-1 suggest that MDP induces a conformational change in NLRP1 that allows it to bind nucleotides and oligomerize, creating a binding platform for caspase-1 (Faustin et al. 2008). There is no direct evidence that NLRP1 binds MDP so the mechanism that stimulates NLRP1 is unclear.
Reaction - small molecule participants:
MDP [cytosol]
Reactome.org reaction link: R-HSA-844447
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Reaction input - small molecules:
muramyl dipeptide
Reaction output - small molecules:
Reactome.org link: R-HSA-844447