Reaction: ATP binds to P2X7
- in pathway: The NLRP3 inflammasome
P2X7 is a receptor for extracellular ATP that acts as a ligand gated non-selective cation channel. It is also responsible for the ATP-dependent lysis of macrophages, which it brings about by mediating the formation of membrane pores permeable to large molecules (Adinolfi et al. 2005).
Reaction - small molecule participants:
ATP [extracellular region]
Reactome.org reaction link: R-HSA-877178
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
Reactome.org link: R-HSA-877178