Reaction: P2X7 mediates loss of intracellular K+
- in pathway: The NLRP3 inflammasome
Low level or transient activation of P2X7 leads to reversible opening of a membrane channel permeable to small cations such as Na+, Ca2+ and K+ (Adinolfi et al. 2005).
Reaction - small molecule participants:
K+ [extracellular region]
K+ [cytosol]
Reactome.org reaction link: R-HSA-877187
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Reaction input - small molecules:
potassium(1+)
Reaction output - small molecules:
potassium(1+)
Reactome.org link: R-HSA-877187