Reaction: PNPLA7 hydrolyzes LysoPtdCho
- in pathway: Glycerophospholipid catabolism
PNPLA7 (Patatin-like phospholipase domain-containing protein 7, also known as NRE - NTE-related esterase) associated with the endoplasmic reticulum membrane catalyzes the hydrolysis of LysoPtcCho (lysophosphatidylcholine) to GPCho (glycerophosphocholine) and LCFA (long chain fatty acid). The human enzyme is expressed most abundantly in prostate, pancreas, and adipose tissues (Wilson et al. 2006). Its location and enzymatic activity have been inferrred from the properties of its mouse homologue (Kienesberger et al. 2008).
Reaction - small molecule participants:
GPCho [cytosol]
LCFA(-) [endoplasmic reticulum membrane]
H2O [cytosol]
LysoPtdCho [endoplasmic reticulum membrane]
Reactome.org reaction link: R-HSA-8847912
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Reaction input - small molecules:
water
1-O-acyl-sn-glycero-3-phosphocholine
Reaction output - small molecules:
choline alfoscerate
long-chain fatty acid anion
Reactome.org link: R-HSA-8847912