Reaction: PNPLA4 hydrolyzes TAG
- in pathway: Triglyceride catabolism
PNPLA4 (patatin-like phospholipase domain-containing protein 4, also known as GS2 and iPLA2(eta)) catalyzes the hydrolysis of TAG (triacylglycerol) to DAG (diacylglycerol) and one molecule of LCFA (long chain fatty acid). The enzyme also has transacylase activity not annotated here (Gao and Simon 2007; Jenkins et al. 2004).
Reaction - small molecule participants:
LCFA(-) [cytosol]
DAG [cytosol]
H2O [cytosol]
TAG [cytosol]
Reactome.org reaction link: R-HSA-8848338
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Reaction input - small molecules:
water
triglyceride
Reaction output - small molecules:
long-chain fatty acid anion
1,2-diacyl-sn-glycerol
Reactome.org link: R-HSA-8848338