Reaction: PNPLA4 hydrolyzes retinyl palmitate
- in pathway: Triglyceride catabolism
PNPLA4 (patatin-like phospholipase domain-containing protein 4, also known as GS2 and iPLA2(eta)) catalyzes the hydrolysis of atR-PALM (all-trans retinyl palmitate) to atROL (all-trans retinol) and a molecule of PALM (palmitate) (Gao and Simon 2006; Gao and Simon 2007). The reaction is inhibited by cytosolic PLIN3 (perilipin 3). The enzyme may also catalyze transacylation reactions to form retinyl esters or promote the activity of other enzymes that do so (Gao et al. 2009).
Reaction - small molecule participants:
PALM(-) [cytosol]
atROL [cytosol]
H2O [cytosol]
atR-PALM [cytosol]
Reactome.org reaction link: R-HSA-8848355
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Reaction input - small molecules:
water
all-trans-retinyl palmitate
Reaction output - small molecules:
hexadecanoate
all-trans-retinol
Reactome.org link: R-HSA-8848355