Reaction: DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG
- in pathway: Acyl chain remodeling of DAG and TAG
DGAT2L6 (Diacylglycerol O-acyltransferase 2-like protein 6, also known as DC3) catalyzes the transfer of an acyl group from acyl-CoA to DAG (diacylglycerol) to form TAG (triacylglycerol). DGAT2L6 catalyzes this reaction with low efficiency in vitro so its physiological role is uncertain. Based on its similarity to other proteins of the DGAT family it is inferred to be localized to the endoplasmic reticulum membrane (Turkish et al. 2005). The putative diacylglycerol O-acyltransferase 2-like protein DGAT2L7P may also possess the same activity as DGAT2L6.
Reaction - small molecule participants:
TAG [endoplasmic reticulum membrane]
CoA-SH [cytosol]
acyl-CoA [cytosol]
DAG [endoplasmic reticulum membrane]
Reactome.org reaction link: R-HSA-8848580
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Reaction input - small molecules:
acyl-CoA
1,2-diacyl-sn-glycerol
Reaction output - small molecules:
triglyceride
coenzyme A(4-)
Reactome.org link: R-HSA-8848580