Reaction: AWAT2 transfers PALM from PALM-CoA to atROL, forming atR-PALM
- in pathway: Wax biosynthesis
AWAT2 (Acyl-CoA wax alcohol acyltransferase 2, also known as MFAT and DC4) associated with the endoplasmic reticulum membrane catalyzes the reaction of atROL (all-trans retinol) and PALM-CoA (palmitoyl-CoA) to form the ester retinyl palmitate. This ester is thought to provide an inactive storage form of retinol and might play a role in protecting skin, where AWAT2 is most abundant from the effects of UV light (Arne et al. 2017; Yen et al. 2005).
Reaction - small molecule participants:
CoA-SH [cytosol]
atR-PALM [cytosol]
PALM-CoA [cytosol]
atROL [cytosol]
Reactome.org reaction link: R-HSA-8848585
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Reaction input - small molecules:
palmitoyl-CoA(4-)
all-trans-retinol
Reaction output - small molecules:
coenzyme A(4-)
all-trans-retinyl palmitate
Reactome.org link: R-HSA-8848585