Reaction: PTK6 phosphorylates ARAP1
- in pathway: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
ARAP1 is implicated in the endocytosis of EGFR, as the complex formation betwen ARAP1 and CIN85 inhibits CBL-mediated targeting of EGFR to the early endosome/lysosome pathway (Yoon et al. 2011). PTK6 phosphorylates ARAP1 on tyrosine residue Y231, resulting in the inhibition of EGFR endocytosis and, hence, prolonged EGFR signaling (Kang et al. 2010).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-8848873
======
Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-8848873