Reaction: PTK6 phosphorylates KHDRBS1
- in pathway: PTK6 Regulates Proteins Involved in RNA Processing
PTK6 phosphorylates KHDRBS1 (SAM68) on tyrosine residues Y435, Y440 and Y443, located within the nuclear localization signal (NLS) of KHDRBS1 (Lukong et al. 2005). PTK6-mediated phosphorylation inhibits the interaction of KHDRBS1 with RNA (Derry et al. 2000, Coyle et al. 2003).
Reaction - small molecule participants:
ADP [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-8848975
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-8848975