Reaction: LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine
- in pathway: COPI-independent Golgi-to-ER retrograde traffic
AGPAT3 is an acyltransferase that can act on lysophosphatidylcholine to generate phosphatidylcholine (Prasad et al, 2011; Echard at al, 1998). This activity may counter the membrane tubule-inducing activity of Golgi PLA2 enzymes, thus favouring COPI-dependent vesicle formation over COPI-indendent retrograde traffic. While many lysophospholipid acyltransferases are ER-localized, AGPAT3 has been shown to also be present at the Golgi membrane, making it well situated to counter PLA2 activity during membrane tubule formation (Drecktah et al, 2003; Schmidt et al, 2009; reviewed in Ha et al, 2012; Heffernan and Simpson, 2014).
Reaction - small molecule participants:
PC [Golgi membrane]
CoA-SH [cytosol]
AA-CoA [cytosol]
2-lysophosphatidylcholine [Golgi membrane]
Reactome.org reaction link: R-HSA-8849345
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Reaction input - small molecules:
arachidonoyl-CoA(4-)
1-O-acyl-sn-glycero-3-phosphocholine(1+)
Reaction output - small molecules:
1,2-diacyl-sn-glycero-3-phosphocholine
coenzyme A(4-)
Reactome.org link: R-HSA-8849345