Reaction: PTK6 phosphorylates SFPQ
- in pathway: PTK6 Regulates Proteins Involved in RNA Processing
PTK6 (BRK) binds a large RNA processing nuclear complex that contains SFPQ (PSF) and phosphorylates SFPQ on C-terminal tyrosine residues. PTK6 also phosphorylates at least two additional SFPQ-associated unidentified proteins.
PTK6-mediated phosphorylation disrupts SFPQ binding to RNA and may promote the relocalization of SFPQ to the cytosol and cell cycle arrest (Lukong et al. 2009).
Reaction - small molecule participants:
ADP [nucleoplasm]
ATP [nucleoplasm]
Reactome.org reaction link: R-HSA-8849463
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-8849463