Reaction: ST14 hydrolyzes and activates KLK5
- in pathway: Formation of the cornified envelope
ST14 (Suppressor of tumorigenicity 14, also known as matriptase) associated with the plasma membrane catalyzes the hydrolytic cleavage of proKLK5 (pro-Kallekrein-5) to yield active KLK5 enzyme. The activity of human ST14 enzyme is inferred from that of its well-characterized mouse homolog (Sales et al. 2010). Consistent with this inference, deficiencies of the human enzyme are associated with an ichthyosis syndrome (MIM 602400) as is a knockout mutation of mouse St14 (Alef et al. 2009).
Reaction - small molecule participants:
H2O [extracellular region]
Reactome.org reaction link: R-HSA-8849826
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Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-8849826