Reaction: KLK5 cleaves and activates CELA2
- in pathway: Formation of the cornified envelope
In the low-pH environment of the upper layers of the stratum corneum, KLK5 (Kallikrein 5) dissociates from its complex with SPINK5 (Serine protease inhibitor kazal-type 5) (Deraison et al. 2007) and is free to cleave proCELA2 (Elastase 2), activating it (Bonnart et al. 2010).
Reaction - small molecule participants:
H2O [extracellular region]
Reactome.org reaction link: R-HSA-8849857
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Reaction input - small molecules:
water
Reaction output - small molecules:
Reactome.org link: R-HSA-8849857