Reaction: NTPDase1 hydrolyzes nucleoside diphosphates
- in pathway: Phosphate bond hydrolysis by NTPDase proteins
NTPDase1 (CD39), a plasma membrane-bound nucleotide phosphatase encoded by the ENTPD1 gene, hydrolyzes extracellular NDPs to corresponding NMPs (Lemmens et al. 2000, Kukulski et al. 2005) which contributes to inhibition of platelet aggregation and thrombosis (Kaczmarek et al. 1996, Enjyoji et al. 1999, Marcus et al. 2003).
Reaction - small molecule participants:
H+ [extracellular region]
Pi [extracellular region]
NMP [extracellular region]
H2O [extracellular region]
NDP [extracellular region]
Reactome.org reaction link: R-HSA-8850854
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Reaction input - small molecules:
water
nucleoside 5'-diphosphate(3-)
Reaction output - small molecules:
hydron
hydrogenphosphate
nucleoside 5'-monophosphate(2-)
Reactome.org link: R-HSA-8850854