Reaction: NTPDase4 hydrolyzes nucleoside diphosphates
- in pathway: Phosphate bond hydrolysis by NTPDase proteins
NTPDase4 (UDPase), encoded by the ENTPD4 gene, belongs to the E-NTPDase family of nucleotide phosphatases. NTPDase4 localizes to the Golgi membrane, with active site on the Golgi lumen side. In the presence of Ca2+, NTPDase4 hydrolyzes nucleoside diphosphates UDP, GDP, CDP and dTDP to nucleoside monophosphates UMP, GMP, CMP and dTMP, respectively (Wang and Guidotti 1998).
Reaction - small molecule participants:
Pi [Golgi lumen]
H+ [Golgi lumen]
H2O [Golgi lumen]
Reactome.org reaction link: R-HSA-8851225
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Reaction input - small molecules:
water
Reaction output - small molecules:
hydrogenphosphate
hydron
Reactome.org link: R-HSA-8851225