Reaction: NTPDase4 hydrolyzes nucleoside triphosphates
- in pathway: Phosphate bond hydrolysis by NTPDase proteins
NTPDase4 (UDPase), encoded by the ENTPD4 gene, is an E-NTPDase family member that localizes to the Golgi membrane and can hydrolyze nucleoside triphosphates UTP, GTP, CTP and TTP to nucleoside diphosphates UDP, GDP, CDP and TDP, respectively, in the Golgi lumen. NTPDase4 hydrolyzes nucleoside triphosphates less efficiently than nucleoside diphosphates. Ca2+ is needed for NTPDase4 activity (Wang and Guidotti 1998).
Reaction - small molecule participants:
Pi [Golgi lumen]
H+ [Golgi lumen]
H2O [Golgi lumen]
Reactome.org reaction link: R-HSA-8851234
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Reaction input - small molecules:
water
Reaction output - small molecules:
hydrogenphosphate
hydron
Reactome.org link: R-HSA-8851234