Meta-Biol

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NTPDase7 (LALP1), encoded by the ENTPD7 gene, is a cytoplasmic vesicle membrane-bound nucleotide phosphatase that hydrolyzes nucleoside triphosphates CTP, GTP and UTP to nucleoside diphosphates CDP, GDP and UDP, respectively. NTPDase7 may have a low activity towards ATP and nucleoside diphosphates (Shi et al. 2001). NTPDase7 requires Ca2+ for catalytic activity (Shi et al. 2001). In mice, NTPDase7 was shown to regulate development of IL17-secreting Th17 cells in the small intestine, possibly by regulating extracellular ATP levels (Kusu et al. 2013).