Reaction: NTPDase8 hydrolyzes nucleoside triphosphates
- in pathway: Phosphate bond hydrolysis by NTPDase proteins
NTPDase8, encoded by the ENTPD8 gene, is an E-NTPDase family ectonucleotide phosphatase that, in the presence of Ca2+ or Mg2+, hydrolyzes NTPs to NMPs, via corresponding NDP intermediates. NTPDase8 is more efficient in hydrolyzing NTPs than NDPs. NTPDase8 provides the main ectonucleotide phosphatase activity in rat and porcine livers (Sevigny et al. 2000, Fausther et al. 2007).
Reaction - small molecule participants:
H+ [extracellular region]
Pi [extracellular region]
H2O [extracellular region]
Reactome.org reaction link: R-HSA-8851538
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Reaction input - small molecules:
water
Reaction output - small molecules:
hydron
hydrogenphosphate
Reactome.org link: R-HSA-8851538