Reaction: GALNT3 transfers GalNAc to FGF23
- in pathway: FGFR3c ligand binding and activation
Fibroblast growth factor 23 (FGF23, aka phosphatonin) is a regulator of phosphate homeostasis and vitamin D metabolism. Its effects are thought to be mediated via the FGFR3c receptor. Glycosylation is necessary for FGF23 secretion from the cell and that is mediated by polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3), which transfers an N-acetylgalactosaminyl (GalNAc) moiety from a high energy donor to threonine 178 on FGF23 (Kato et al. 2006). Competition between proprotein convertase cleavage and O-glycosylation determines the level of secreted active FGF23.
Reaction - small molecule participants:
UDP [Golgi lumen]
UDP-GalNAc [Golgi lumen]
Reactome.org reaction link: R-HSA-8851619
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Reaction input - small molecules:
UDP-N-acetyl-D-galactosamine(2-)
Reaction output - small molecules:
UDP(3-)
Reactome.org link: R-HSA-8851619