Reaction: GPR183 binds 7alpha,25-dihydroxycholesterol
- in pathway: Class A/1 (Rhodopsin-like receptors)
GPR183 (Epstein-Barr virus-induced gene 2, EBI2) is a G protein-coupled receptor that is expressed in peripheral blood mononuclear cells and the CNS. It is activated by the oxysterol 7-alpha-25-dihydroxycholesterol (7A25HC) (Hannedouche et al. 2011). EBI2 is coupled exclusively to Gi (Rosenkilde et al. 2006).
Reaction - small molecule participants:
7alpha,25-dihydroxycholesterol [extracellular region]
Reactome.org reaction link: R-HSA-8851679
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Reaction input - small molecules:
7alpha,25-dihydroxycholesterol
Reaction output - small molecules:
Reactome.org link: R-HSA-8851679