Reaction: MST1R autophosphorylates
- in pathway: Signaling by MST1
In response to ligand binding and receptor dimerisation, macrophage-stimulating protein receptor (MST1R aka RON) autophosphorylates on Tyr-1238 and Tyr-1239 in the kinase domain. This leads to further phosphorylation of Tyr-1353 and Tyr-1360 in the C-terminal multifunctional docking site (Yokoyama et al. 2005, Wang et al. 2010).
Reaction - small molecule participants:
ADP [cytosol]
ATP [cytosol]
Reactome.org reaction link: R-HSA-8852552
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Reaction input - small molecules:
ATP(4-)
Reaction output - small molecules:
ADP(3-)
Reactome.org link: R-HSA-8852552