Meta-Biol

• Pathways

FGFR2 fusions in cholangiocarcinoma and cancers of the breast, lung and thyroid have been shown to promote anchorage independent growth, cellular proliferation and tumorigenesis. In some cases, such as for FGFR2-AHCYL1 and FGFR2-BICC1 fusions in cholangiocarcinoma, these activities have been shown to depend on the FGFR2 kinase domain, suggesting that the fusions undergo autophosphorylation after oligomerization, as is the case for WT FGFR2. FGFR2 fusions, where tested, also show sensitivity to kinase inhibitors such as PD173074 and pazopanib (Arai et al, 2013; Wu et al, 2013; Seo et al, 2012; reviewed in Parker et al, 2014).