Reaction: FGFR2IIIa TM binds ligand and full length receptors to inhibit signaling
- in pathway: Signaling by FGFR2 IIIa TM
By BIAcore assay, FGFR2 IIIa TM has been shown to bind FGF1, and in the presence of chip-bound FGFR2b or 2c, to form an FGF1-dependent heterodimer. In COS cells stimulated with FGF2, expression of FGFR IIIa TM abrogates FGF signaling and stabilizes the full length receptors at the cell surface. Consistent with this, in vivo expression of FGFR2 IIIa TM abrogates expression of the FGFR target gene MKP3. These data support the idea that FGFR2 IIIa TM inhibits FGFR signaling by binding and sequestering ligand and/or forming non-functional heterodimers with full-length receptors (Wheldon et al, 2011).
Reaction - small molecule participants:
HS [extracellular region]
Reactome.org reaction link: R-HSA-8853320
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Reaction input - small molecules:
heparan sulfate
Reaction output - small molecules:
Reactome.org link: R-HSA-8853320