Reaction: TBC1D16 accelerates GTP hydrolysis by RAB4A
- in pathway: TBC/RABGAPs
RAB4A is a master regulator of receptor recycling from endocytic compartments to the plasma membrane. It is involved in transferrin receptor recycling and EGFR trafficking and signalling. TBC (Tre2/Bub2/Cdc16) domain family member 16 (TBC1D16), is a GTPase activating protein for Rab4A and enhances the intrinsic rate of GTP hydrolysis by RAB4A (Goueli et al. 2012).
Reaction - small molecule participants:
Pi [cytosol]
H2O [cytosol]
Reactome.org reaction link: R-HSA-8854604
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Reaction input - small molecules:
water
Reaction output - small molecules:
hydrogenphosphate
Reactome.org link: R-HSA-8854604