Reaction: ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane
- in pathway: Glycosphingolipid biosynthesis
Mammalian cells ubiquitously express three extended-synaptotagmins 1 to 3 (ESYT1-3) which function as Ca2+-regulated endoplasmic reticulum-plasma membrane (ER-PM) tethers. They form homo- and hetero-meric complexes on the ER membrane (heterotrimer shown in this example), are dependent on PI(4,5)P2 in plasma membranes and regulated by cytosolic Ca2+ via the Ca2+-sensing property of ESYT1. An increase in Ca2+ levels contributes to ER-PM tethering, allowing ESYTs to play a putative role in transport of lipids such as glycerophospholipids (GPL) between the two membranes (Giordano et al. 2013, Idevall-Hagren et al. 2015).
Reaction - small molecule participants:
GPL [endoplasmic reticulum membrane]
GPL [plasma membrane]
Reactome.org reaction link: R-HSA-8857662
======
Reaction input - small molecules:
glycerophospholipid
Reaction output - small molecules:
glycerophospholipid
Reactome.org link: R-HSA-8857662